Fumarate reductase superfamily: A diverse group of enzymes whose evolution is correlated to the establishment of different metabolic pathways
| Autor: | Rafael Rauber, Douglas Jardim-Messeder, Márcia Margis-Pinheiro, Rogério Margis, Caroline Cabreira-Cagliari, Andreia Carina Turchetto-Zolet |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification 030102 biochemistry & molecular biology Succinate dehydrogenase Succinates SUPERFAMILY Cell Biology Biology Fumarate reductase Biological Evolution Succinate Dehydrogenase 03 medical and health sciences Metabolic pathway 030104 developmental biology Enzyme Fumarates chemistry Biochemistry biology.protein Molecular Medicine Molecular Biology Biotransformation Metabolic Networks and Pathways |
| Zdroj: | Mitochondrion. 34:56-66 |
| ISSN: | 1567-7249 |
| DOI: | 10.1016/j.mito.2017.01.002 |
| Popis: | Fumarate and succinate are known to be present in prebiotic systems essential for the origin of life. The fumarate and succinate interconversion reactions have been conserved throughout evolution and are found in all living organisms. The fumarate and succinate interconversion is catalyzed by the enzymes succinate dehydrogenase (SDH) and fumarate reductase (FRD). In this work we show that SDH and FRD are part of a group of enzymes that we propose to designate “fumarate reductase superfamily”. Our results demonstrate that these enzymes emerged from a common ancestor and were essential in the development of metabolic pathways involved in energy transduction. |
| Databáze: | OpenAIRE |
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