Resistance to β-lactams in Streptococcus pneumoniae
| Autor: | Laura Vigliarolo, Horacio Angel Lopardo, Sara Kaufman, Marta Mollerach, Inés Toresani, Laura Bonofiglio, Gabriela García Gabarrot, Paula Gagetti, Martha H. von Specht |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Penicillin binding proteins medicine.drug_class Penicillin Resistance Antibiotics Argentina Microbial Sensitivity Tests beta-Lactams medicine.disease_cause Microbiology Pneumococcal Infections 03 medical and health sciences Streptococcus pneumoniae medicine Humans 0303 health sciences 030306 microbiology business.industry General Medicine medicine.disease Anti-Bacterial Agents Penicillin Pneumonia Otitis Bacteremia medicine.symptom business Meningitis medicine.drug |
| Zdroj: | Revista Argentina de Microbiología. 53:266-271 |
| ISSN: | 0325-7541 |
| Popis: | Streptococcus pneumoniae is an important causal agent of pneumonia, meningitis, sepsis, bacteremia, and otitis media. Penicillin resistance rates in S. pneumoniae have remained stable in Argentina in the last years. In the late '90s more isolates with MIC of penicillin ≥2μg/ml were observed; however, their frequency has decreased in recent years. The phenotypic expression of penicillin resistance is due to a modification in penicillin-binding proteins associated with a mosaic structure in the coding genes. The expansion of successful resistant clones varies among the different regions and is influenced by the use of antibiotics, vaccines, particularly conjugated ones, as well as population density. Parenteral treatment with high doses of penicillin G continues to be effective for the treatment of pneumonia and bacteremia, oral aminopenicillins for otitis media and sinusitis and third generation cephalosporins for meningitis. |
| Databáze: | OpenAIRE |
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