A cold spot compensation technique using a combination of trans-rectal ultrasonography and intraoperative computed tomography for interstitial permanent prostate brachytherapy: a single-arm prospective trial
| Autor: | Takefumi Satoh, Masatsugu Iwamura, Akane Sekiguchi, Ken-ichi Tabata, Hiromichi Ishiyama, Hideyasu Tsumura, Kazushige Hayakawa, Shogo Kawakami |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Original Paper
medicine.diagnostic_test Cold spot business.industry medicine.medical_treatment Brachytherapy brachytherapy Permanent prostate brachytherapy Computed tomography intraoperative CT medicine.disease prostate cancer Prostate cancer medicine.anatomical_structure Oncology O-arm system Prostate medicine Radiology Nuclear Medicine and imaging low-dose-rate Ultrasonography business Nuclear medicine Prostate brachytherapy |
| Zdroj: | Journal of Contemporary Brachytherapy |
| ISSN: | 2081-2841 1689-832X |
| Popis: | Purpose To evaluate the efficacy of a cold spot compensation technique using a combination of trans-rectal ultrasonography (TRUS) and computed tomography (CT) for permanent interstitial prostate brachytherapy. Material and methods Sixty-five patients were treated with the cold spot compensation technique using TRUS-CT fusion. The prescribed dose was set at 145 Gy. The dose to 90% of prostate volume (D90) was planned to be within 195 Gy (134%) and 205 Gy (141%). After implantation using the conventional technique, additional seeds were implanted if cold spots were detected on TRUS-CT fusion images. Results Cold spots were detected in 32 of 65 patients (49%) and were compensated by additional seeds. Median number of additional seeds was 3 (range, 1-5). A CT scan 1 month later revealed that the percentage of patients receiving an undesirably low D90 (160-180 Gy) was significantly reduced in the examination arm compared to historical controls. However, mean operation time was significantly longer in the examination arm (64 min) than in historical controls (49 min, p < 0.001). With median follow-up of 18 months (range, 9-24 months), no grade 3 or worse toxicity was encountered. Conclusion The cold spot compensation technique using TRUS-CT fusion appears effective for patients receiving permanent interstitial prostate brachytherapy. |
| Databáze: | OpenAIRE |
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