Role of corpus callosum integrity in arm function differs based on motor severity after stroke
| Autor: | Lucy Dodakian, Jill See, Jill Campbell Stewart, Steven C. Cramer, George Tran, Erin Burke Quinlan, Pritha Dewanjee, Alison McKenzie |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_treatment Pyramidal Tracts Corpus callosum physiopathology [Arm] Severity of Illness Index lcsh:RC346-429 Corpus Callosum 0302 clinical medicine Medicine and Health Sciences Image Processing Computer-Assisted complications [Stroke] 10. No inequality Stroke Aged 80 and over Movement Disorders Rehabilitation diagnostic imaging [Pyramidal Tracts] Regular Article Middle Aged White Matter Diffusion Tensor Imaging Motor Neurology Arm lcsh:R858-859.7 Female diagnostic imaging etiology pathology [Movement Disorders] Psychology Adult medicine.medical_specialty Cognitive Neuroscience Sensory system lcsh:Computer applications to medicine. Medical informatics diagnostic imaging [White Matter] Young Adult 03 medical and health sciences Physical medicine and rehabilitation Arm function Fractional anisotropy medicine Humans Radiology Nuclear Medicine and imaging lcsh:Neurology. Diseases of the nervous system Aged diagnostic imaging [Corpus Callosum] medicine.disease 030104 developmental biology Corticospinal tract Anisotropy Neurology (clinical) Neuroscience 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 14, Iss C, Pp 641-647 (2017) Stewart, Jill Campbell; Dewanjee, Pritha; Tran, George; Quinlan, Erin Burke; Dodakian, Lucy; McKenzie, Alison; et al.(2017). Role of corpus callosum integrity in arm function differs based on motor severity after stroke.. NeuroImage. Clinical, 14, 641-647. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/3p2508n0 |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2017.02.023 |
| Popis: | While the corpus callosum (CC) is important to normal sensorimotor function, its role in motor function after stroke is less well understood. This study examined the relationship between structural integrity of the motor and sensory sections of the CC, as reflected by fractional anisotropy (FA), and motor function in individuals with a range of motor impairment level due to stroke. Fifty-five individuals with chronic stroke (Fugl-Meyer motor score range 14 to 61) and 18 healthy controls underwent diffusion tensor imaging and a set of motor behavior tests. Mean FA from the motor and sensory regions of the CC and from corticospinal tract (CST) were extracted and relationships with behavioral measures evaluated. Across all participants, FA in both CC regions was significantly decreased after stroke (p 39), motor status correlated with FA in the CC but not the CST, while in individuals with relatively greater motor impairment (Fugl-Meyer motor score ≤ 39), motor status correlated with FA in the CST but not the CC. The role interhemispheric motor connections play in motor function after stroke may differ based on level of motor impairment. These findings emphasize the heterogeneity of stroke, and suggest that biomarkers and treatment approaches targeting separate subgroups may be warranted. Highlights • Corpus callosum structural integrity could impact motor function after stroke. • Corpus callosum integrity was decreased and correlated with motor function. • Correlation was strongest in the subgroup with relatively greater motor capacity. • In subgroup with less motor capacity, only CST integrity correlated with motor function. |
| Databáze: | OpenAIRE |
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