A 'Golden Age' for the discovery of new antileishmanial agents: Current status of leishmanicidal gold complexes and prospective targets beyond the trypanothione system
| Autor: | Josielle V. Fontes, Laiane S. Oliveira, Danilo C. Miguel, Camilla Abbehausen, Rochanna L. Aires, Leticia B. Rosa |
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| Rok vydání: | 2021 |
| Předmět: |
Spermidine
Trypanothione Antiprotozoal Agents Computational biology 01 natural sciences Biochemistry chemistry.chemical_compound Gold Compounds Parasitic Sensitivity Tests Drug Discovery Medicine Animals Humans General Pharmacology Toxicology and Pharmaceutics Leishmaniasis Pharmacology Antitumor activity Leishmania 010405 organic chemistry business.industry Organic Chemistry Glutathione 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Molecular Medicine business Organogold Compounds Oxidation-Reduction |
| Zdroj: | ChemMedChem. 16(11) |
| ISSN: | 1860-7187 |
| Popis: | Leishmaniasis is one of the most neglected diseases worldwide and is considered a serious public health issue. The current therapeutic options have several disadvantages that make the search for new therapeutics urgent. Gold compounds are emerging as promising candidates based on encouraging in vitro and limited in vivo results for several AuI and AuIII complexes. The antiparasitic mechanisms of these molecules remain only partially understood. However, a few studies have proposed the trypanothione redox system as a target, similar to the mammalian thioredoxin system, pointed out as the main target for several gold compounds with significant antitumor activity. In this review, we present the current status of the investigation and design of gold compounds directed at treating leishmaniasis. In addition, we explore potential targets in Leishmania parasites beyond the trypanothione system, taking into account previous studies and structure modulation performed for gold-based compounds. |
| Databáze: | OpenAIRE |
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