EETs/sEH in diabetes and obesity-induced cardiovascular diseases
| Autor: | Jing Weng, Mong Heng Wang, Hui Huang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Epoxide hydrolase 2 medicine.medical_specialty Physiology 030204 cardiovascular system & hematology Biochemistry 03 medical and health sciences chemistry.chemical_compound 8 11 14-Eicosatrienoic Acid 0302 clinical medicine Diabetes mellitus Internal medicine Diabetes Mellitus medicine Animals Humans Obesity Endothelial dysfunction Epoxide Hydrolases Pharmacology chemistry.chemical_classification Type 1 diabetes Chemistry Type 2 Diabetes Mellitus Cell Biology Monooxygenase medicine.disease 030104 developmental biology Endocrinology Solubility Cardiovascular Diseases cardiovascular system lipids (amino acids peptides and proteins) Arachidonic acid Polyunsaturated fatty acid |
| Zdroj: | Prostaglandins & Other Lipid Mediators. 125:80-89 |
| ISSN: | 1098-8823 |
| Popis: | Despite the optimization of blood glucose control and the therapeutic management of risk factors, obesity- and diabetes-induced cardiovascular diseases are still major health problems in the United States. Arachidonic acid (AA), an endogenous 20-carbon polyunsaturated fatty acid, is metabolized by cytochrome P450 (CYP) epoxygenases into epoxyeicosatrienoic acids (EETs), which are important lipid mediators with many beneficial effects in type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and obesity- and diabetes-induced cardiovascular diseases. EETs can be further metabolized to less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). It has been demonstrated that the use of sEH blockers, which prevent EET degradation, is a promising pharmacological approach to promoting insulin secretion, preventing endothelial dysfunction, decreasing blood pressure, and protecting against target organ damage in obesity and metabolic diseases. This review will focus on biochemistry of CYP monooxygenase system as well as the pharmacology and physiological significance of EETs and sEH. We will also discuss the role of EETs/sEH in T1DM, T2DM, and obesity- and diabetes-induced cardiovascular diseases. |
| Databáze: | OpenAIRE |
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