Effects of rice bran hemicellulose on 1,2‐dimethylhydrazine‐induced intestinal carcinogenesis in fischer 344 rats
| Autor: | Taishi Oda, Teiichi Tojima, Takeo Mizutani, Maki Tanaka, Kiyoshi Tatsumi, Seiichiro Aoe |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.medical_treatment Intraperitoneal injection Medicine (miscellaneous) Biology Colon tumors Basal (phylogenetics) chemistry.chemical_compound Polysaccharides Internal medicine Intestinal Neoplasms medicine Animals Hemicellulose Cecum Dimethylhydrazines Intestinal carcinogenesis Nutrition and Dietetics Bran Incidence Body Weight Oryza Hydrogen-Ion Concentration Rats Inbred F344 1 2-Dimethylhydrazine Rats Endocrinology Oncology chemistry Carcinogens Acids |
| Zdroj: | Nutrition and Cancer. 20:41-49 |
| ISSN: | 1532-7914 0163-5581 |
| DOI: | 10.1080/01635589309514269 |
| Popis: | The effect of rice bran hemicellulose (RBH) on 1,2‐dimethylhydrazine‐ (DMH) induced intestinal carcinogenesis was studied in male Fischer 344 rats. Rats were fed a basal control diet or a diet containing 2% or 4% RBH at five weeks of age. At 6 weeks of age, all animals were given an intraperitoneal injection of DMH (20 mg/kg body wt) at weekly intervals for 20 weeks and autopsied 7 weeks after the last injection. The incidence of DMH‐induced colon tumors was significantly lower in rats fed the 4% RBH diet than in rats fed the basal control diet (p < 0.05). The number of colon tumors per rat was also significantly lower in rats fed the 4% RBH diet than in rats fed the basal control diet (p < 0.05). The present study suggested that the water‐soluble RBH played a preventive role in DMH‐induced large bowel carcinogenesis in Fischer 344 rats. |
| Databáze: | OpenAIRE |
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