MiRNA-21 has effects to protect kidney injury induced by sepsis
| Autor: | Dian Fu, Chaopeng Tang, Wen Cheng, Ping Li, Jing-Ping Ge, Zhengyu Zhang, Zhenyu Xu, Wen-Quan Zhou, Jie Dong, Chen Xia |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Apoptosis Punctures Kidney Protective Agents Cell Line Sepsis Phosphatidylinositol 3-Kinases 03 medical and health sciences 0302 clinical medicine microRNA medicine Animals Humans PTEN Rats Wistar Ligation Protein kinase B PI3K/AKT/mTOR pathway Pharmacology biology business.industry Akt/PKB signaling pathway PTEN Phosphohydrolase Acute kidney injury General Medicine Acute Kidney Injury medicine.disease Rats Disease Models Animal MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Immunology biology.protein Cancer research Female business Proto-Oncogene Proteins c-akt Signal Transduction |
| Zdroj: | Biomedicine & Pharmacotherapy. 94:1138-1144 |
| ISSN: | 0753-3322 |
| Popis: | To investigate the miRNA-21 over-expression in the acute kidney injury induced by sepsis, we developed a sepsis induced in vitro model by lip polysaccharide (LPS) and in vovo model by cecal ligation and puncture (CLP) surgery. LPS or CLP surgery induced kidney cell apoptosis increasing. However, the kidney injury indexes of miRNA groups which were transfected with miRNA-21 were significantly suppressed. In further study, the relative proteins expressions were evaluated to explain the miRNA-21 mechanism to improve sepsis induced kidney cell apoptosis. The results were shown that miRNA-21 over-expression had effects to protect kidney cell apoptosis induced by sepsis via PTEN/PI3K/AKT signaling pathway. |
| Databáze: | OpenAIRE |
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