Chemotherapy Plus Radiation in Advanced-Stage Endometrial Cancer
| Autor: | Anita Schwandt, Robert Debernardo, William C. Chen, Charles A. Kunos, Paolo Zola, F. Martra |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Oncology medicine.medical_specialty medicine.medical_treatment Adenocarcinoma Internal medicine Humans Medicine Stage (cooking) Aged Neoplasm Staging Retrospective Studies Aged 80 and over Chemotherapy business.industry Endometrial cancer Obstetrics and Gynecology Retrospective cohort study Chemoradiotherapy Adjuvant Middle Aged medicine.disease endometrial cancer chemotherapy radiotherapy Endometrial Neoplasms Clinical trial Chemotherapy Adjuvant Female business Adjuvant Chemoradiotherapy |
| Zdroj: | International Journal of Gynecologic Cancer. 21:1622-1627 |
| ISSN: | 1525-1438 1048-891X |
| DOI: | 10.1097/igc.0b013e31822b6594 |
| Popis: | HypothesisWe hypothesize that adjuvant radiation and chemotherapy improve the clinical benefit from treatment of advanced-stage endometrial adenocarcinoma.MethodsWe conducted a retrospective review of 125 patient with stage III or IVA endometrial adenocarcinoma who received adjuvant chemotherapy (n = 60) or chemoradiation (n = 65). Primary end points were rate of clinical benefit (ie, the percentage of patients who were alive and disease-free for at least 6 months after the last day of adjuvant treatment) and progression-free and overall survival.ResultsThe addition of radiation to chemotherapy improved the rate of clinical benefit from 55% to 77%. Differences in clinical benefit were attributed to a reduction in the number of pelvic relapses after chemoradiation. There were no substantial differences in the rate of extrapelvic relapse events seen between the chemotherapy alone and chemoradiation groups. Patients receiving radiation had prolonged median progression-free survival (36 vs 17 months in chemotherapy alone) and median overall survival (70 vs 64 months in chemotherapy alone).ConclusionsThe addition of radiation to chemotherapy improved the clinical benefit of patients with stage III or IVA endometrial adenocarcinoma. A clinical trial powered to evaluate clinical benefit and survival outcomes of chemotherapy and radiation is under way. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|