Arylsulfatase A levels in patients with chronic alcoholism
| Autor: | Jacinto Careaga-Olivares, Miguel Angel Zúñiga-Charles, Ricardo M Aguirre, Alejandro Hernández-Téllez, Mercedes Alvarez-Leal |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Paranoid Disorders medicine.medical_specialty Arylsulfatase A Bipolar Disorder Hallucinations Gastroenterology Blood serum Alcohol-Induced Disorders Nervous System Internal medicine Chronic alcoholism medicine Humans In patient Bipolar disorder Aspartate Aminotransferases Cerebroside-Sulfatase Aged biology business.industry Cerebroside-sulfatase Mental Disorders Alanine Transaminase General Medicine Clinical Enzyme Tests Middle Aged medicine.disease Prognosis Anxiety Disorders Enzyme assay Alcoholism Alanine transaminase biology.protein Physical therapy Female business |
| Zdroj: | Archives of medical research. 31(6) |
| ISSN: | 0188-4409 |
| Popis: | Background The goal of this study was to find the association between low arylsulfatase A (ASA) activity and psychiatric disorders in chronic alcoholic patients. Methods The study was carried out in 30 chronic alcoholic patients (27 male, 3 female); age range was 25–65 years. There were 20 normal controls (18 males, 2 females), and age range was 24–67 years. ASA and routine aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity laboratory tests were measured in blood serum from all patients and control subjects. Results Alcoholic patients with psychiatric disorders have ASA average values of 68.25 nmol/mL/4 h. This is less than averages found in the alcoholics without psychiatric disorders group (82.48 nmol/mL/4 h) and the control group (90.8 nmol/mL/4 h). There were no statistically significant differences among the three groups studied. Alcoholic subjects with elevated activity of AST and ALT (n = 10) have ASA activity average values of 134.82 nmol/mL/4 h), which is 48.8% higher than the control group (90.6 nmol/mL/4 h). These means show statistically significant differences (p Conclusions Results indicate an association between low serum ASA activity and alcoholism. The appearance of psychiatric manifestations could be related to the low activity of this enzyme in chronic alcoholic patients. Alcoholic patients with elevated enzyme activity of AST and ALT in sera also have elevated sera arylsulfatase A (ASA) activity. We consider that these findings may be useful for evaluating the psychiatric state as a prognosis in chronic alcoholic patients, and should be a routine laboratory test in alcoholic patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect