Salivary scintigraphy for Sjögren's syndrome in patients with xerostomia: A retrospective study

Autor: Aquib Bakhsh, M. Nadal, Mahtab Samimi, Annabel Maruani, Benoît Erra, Loïc Vaillant, Maeva Levy, A. Joly
Přispěvatelé: Service de dermatologie, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Régional Universitaire de Tours (CHRU de Tours), King Abdullah Medical City, Partenaires INRAE, MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), U930, Institut National de la Santé et de la Recherche Médicale (INSERM), Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Institut National de la Recherche Agronomique (INRA)-Université de Tours
Rok vydání: 2018
Předmět:
Adult
Male
burning mouth syndrome
medicine.medical_specialty
Pathology
salivary gland scintigraphy
Scintigraphy
Xerostomia
Gastroenterology
Salivary Glands
030218 nuclear medicine & medical imaging
Diagnosis
Differential
Young Adult
03 medical and health sciences
0302 clinical medicine
sicca syndrome
stomatognathic system
Salivary scintigraphy
Salivary gland scintigraphy
Sicca syndrome
Internal medicine
Humans
Medicine
In patient
Radionuclide Imaging
General Dentistry
Aged
Retrospective Studies
Aged
80 and over
030203 arthritis & rheumatology
medicine.diagnostic_test
business.industry
Retrospective cohort study
Middle Aged
Burning mouth syndrome
stomatognathic diseases
Sjogren's Syndrome
ROC Curve
Otorhinolaryngology
Area Under Curve
Female
Sjögren's syndrome
Sjogren s
medicine.symptom
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Oral Diseases
Oral Diseases, Wiley, 2018, 24 (4), pp.552-560. ⟨10.1111/odi.12802⟩
ISSN: 1354-523X
1601-0825
DOI: 10.1111/odi.12802
Popis: Objectives The value of salivary gland scintigraphy in the diagnosis of Sjogren's syndrome remains controversial. The primary aim of this study was to estimate the diagnostic accuracy of salivary gland scintigraphy in the diagnosis of Sjogren's syndrome among 237 patients with xerostomia. Methods We retrospectively compared eight scintigraphy parameters between 106 Sjogren patients and 131 non-Sjogren patients. Results Seven of the eight parameters were significantly decreased in Sjogren patients; however their diagnostic accuracy was low, with AUCs ranging from 0.58 (95% CI 0.50-0.65) to 0.63 (95% CI: 0.55-0.70). The prestimulatory oral activity index allowed discrimination between primary and secondary Sjogren's syndrome (AUC 0.73, 95% CI: 0.62-0.84) and the secretion velocity for parotid glands allowed discrimination between Sjogren patients and Burning Mouth Syndrome patients (AUC 0.71, 95% CI 0.59-0.82). Conclusion The accuracy of scintigraphy parameters for the diagnosis of Sjogren's syndrome among patients with xerostomia was low, however, some functional indices appeared to assist discrimination between primary and secondary SS patients and between sub-groups of patients with different causes of xerostomia. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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