Bone tissue engineering: state of the union
| Autor: | Michael C. McDermott, Arun R. Shrivats, Jeffrey O. Hollinger |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
Pathology medicine.medical_specialty Bone Regeneration Tissue Engineering Tissue Scaffolds business.industry Allogeneic bone graft Clinical success Bone and Bones Bone tissue engineering Risk analysis (engineering) Tissue engineering Drug Discovery Animals Humans Intercellular Signaling Peptides and Proteins Medicine Clinical efficacy Stem cell business |
| Zdroj: | Drug Discovery Today. 19:781-786 |
| ISSN: | 1359-6446 |
| Popis: | The quest to surpass the clinical efficacy of the allogeneic bone graft has had limited success, an outcome that is symbolic of tissue engineering as a whole. In this 'State of the Union'-type review, we highlight recent advances in the design of bone regenerative therapeutics using the primary elements of stem cells, growth factors and scaffolds, and identify major obstacles in their paths to the clinic. We underscore the need for rigorous performance criteria in the design of holistic tissue regenerative therapeutics, and an increased emphasis on the product production, storage and handling issues that will ultimately influence clinical success. |
| Databáze: | OpenAIRE |
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