Serum amyloid A protein and hypoxic ischemic encephalopathy in the newborn
| Autor: | Z. Hamed, A. Lotfy, N. Ramy, Hany Aly, H. Arnaoot, L. Mohsen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Term Birth Encephalopathy Enzyme-Linked Immunosorbent Assay Gastroenterology Hypoxia ischemia Severity of Illness Index Hypoxic Ischemic Encephalopathy Internal medicine Inflammatory marker medicine Humans Serum amyloid A Prospective Studies Postnatal day Acute-Phase Reaction Serum Amyloid A Protein Monitoring Physiologic Asphyxia Neonatorum business.industry Infant Newborn Obstetrics and Gynecology Brain medicine.disease Neonatal Hypoxic Ischemic Encephalopathy Case-Control Studies Data Interpretation Statistical Pediatrics Perinatology and Child Health Hypoxia-Ischemia Brain business Biomarkers |
| Zdroj: | Journal of perinatology : official journal of the California Perinatal Association. 31(4) |
| ISSN: | 1476-5543 |
| Popis: | Serum amyloid A (SAA) is an acute phase inflammatory marker that is closely associated with ischemic injuries. Its expression in neonatal hypoxic ischemic encephalopathy (HIE) has not been studied. To test the hypothesis that SAA is increased in neonatal HIE and its concentration correlates with the severity of encephalopathy.We conducted a prospective case-control study on 54 full-term neonates; 27 cases with evidence of perinatal compromise and 27 healthy controls. Blood samples were collected from cases and controls at postnatal day 1 and day 7, and SAA was measured by ELISA.SAA concentrations (μg ml(-1)) were significantly increased in cases when compared with controls at day 1 and at day 7 (P0.001). SAA concentrations at day 1 were greater in cases who died when compared with those who survived, and correlated significantly with the severity of HIE (146.9 ± 56.4 vs 79.8 ± 24.7 vs 58.1 ± 21.5) in severe, moderate and mild HIE, respectively (P=0.001).The expression of SAA is increased in response to hypoxia ischemia of the neonate. The increased concentration correlates with the severity of encephalopathy and is associated with mortality. This is the first study of SAA in neonatal HIE. |
| Databáze: | OpenAIRE |
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