Wide host range of murine sarcoma virus
| Autor: | Johng S. Rhim, Fuw G. Duh, Mina Lee Vernon, Robert J. Huebner |
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| Rok vydání: | 1973 |
| Předmět: |
Cancer Research
DNA polymerase Swine viruses Porcine kidney Guinea Pigs Simian Kidney Tritium Virus Replication Virus Epitopes Dogs Antigen Culture Techniques Animals Humans Antigens Infectious virus biology Murine sarcoma virus Complement Fixation Tests Embryo RNA-Directed DNA Polymerase Haplorhini biology.organism_classification Embryo Mammalian Virology Molecular biology Rats Microscopy Electron Cell Transformation Neoplastic Retroviridae Oncology biology.protein Cats Cattle Rabbits Gammaretrovirus |
| Zdroj: | International journal of cancer. 12(3) |
| ISSN: | 0020-7136 |
| Popis: | Cultures of canine, rabbit, porcine, avian, feline, bovine, simian and human origin were tested for their susceptibility to the Kirsten murine sarcoma virus (Ki-MSV). Data indicated that Ki-MSV replicates and transforms the cultures of canine embryo, rabbit kidney, porcine kidney, feline embryo, bovine embryo and human tumor cells. These morphologically altered cells contained infectious virus and group-specific (gs) complement-fixing (CF) antigen characteristic of viruses of the murine sarcoma-leukemia complex. The infected cultures produced type-C virus particles. RNA-dependent DNA polymerase activity was also demonstrable in the altered cells. The present results indicate that members of the murine sarcoma-leukemia virus complex, particularly Ki-MSV, exhibit a wider host range than was hitherto believed. |
| Databáze: | OpenAIRE |
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