Drastic morphological and molecular differences between lymph node micrometastatic tumors and macrometastatic tumors of lung adenocarcinoma
| Autor: | Junji Yoshida, Atsushi Ochiai, Genichiro Ishii, Tomoyuki Hishida, Eiji Yamada, Masahiro Tsuboi, Norihiko Ikeda, Motohiro Kojima, Keiju Aokage, Nao Aramaki, Masahiro Morise |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Cancer Research Pathology medicine.medical_specialty Stromal cell Lung Neoplasms CD34 Adenocarcinoma Immunophenotyping 03 medical and health sciences 0302 clinical medicine Tumor budding Internal medicine medicine Humans Neoplasm Invasiveness Lymph node Neoplasm Staging Hematology business.industry Micrometastasis General Medicine medicine.disease Prognosis Carcinoma Papillary 030104 developmental biology medicine.anatomical_structure Oncology Neoplasm Micrometastasis 030220 oncology & carcinogenesis Lymphatic Metastasis Cancer cell business |
| Zdroj: | Journal of cancer research and clinical oncology. 142(1) |
| ISSN: | 1432-1335 |
| Popis: | The expansion of micrometastatic tumors to macrometastatic ones is thought to be tightly regulated by several microenvironmental factors. The aim of this study was to elucidate the morphological and phenotypical differences between micrometastatic and macrometastatic tumors. We first examined the morphological characteristics of 66 lymph node (LN) micrometastatic tumors (less than 2 mm in size) and 51 macrometastatic tumors (more than 10 mm in size) in 42 lung adenocarcinoma cases. Then, we evaluated the expression level of E-cadherin, S100A4, ALDH1, and Geminin in cancer cells and the number of smooth muscle actin (SMA), CD34, and CD204 (+) stromal cells in the primary tumors, matched micrometastatic tumors, and macrometastatic tumors (n = 34, each). Tumor budding reflects the process of EMT, and stromal reactions were observed more frequently in macrometastatic tumors (P |
| Databáze: | OpenAIRE |
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