Early lung ultrasound affords little to the prediction of bronchopulmonary dysplasia
| Autor: | Andrew W. Gill, Patricia Lee Woods, Amanda Woods, Benjamin Stoecklin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Respiratory Therapy medicine.medical_specialty medicine.medical_treatment Gestational Age Logistic regression 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Intensive Care Units Neonatal 030225 pediatrics Humans Medicine Intubation Prospective Studies Neonatology Lung Bronchopulmonary Dysplasia Ultrasonography Duration of Therapy business.industry Obstetrics Infant Newborn Postmenstrual Age Obstetrics and Gynecology Gestational age Pulmonary Surfactants Western Australia General Medicine medicine.disease Lung ultrasound Early Diagnosis 030228 respiratory system Bronchopulmonary dysplasia Pediatrics Perinatology and Child Health Female business Infant Premature Cohort study |
| Zdroj: | Archives of Disease in Childhood - Fetal and Neonatal Edition. 106:657-662 |
| ISSN: | 1468-2052 1359-2998 |
| Popis: | ObjectiveTo test the hypothesis that lung ultrasound (LUS) performed in the first week of life would predict bronchopulmonary dysplasia (BPD). Secondary outcomes included the utility of LUS in predicting interim respiratory interventions.DesignA prospective observational cohort study in preterm infants born MethodsA rigorous protocol for LUS acquisition on day 1, day 3–4, day 7, day 28 and 36 weeks’ postmenstrual age (PMA) was implemented with blinded analysis using a modified, previously validated LUS score. BPD was defined by both recent National Institute of Child Health and Human Development categorical criteria and a continuous physiological variable using a modified Shift test.ResultsOf the 100 infants studies, primary outcome data were available for the 96 infants, surviving to 36 weeks’ PMA. In a univariate logistic regression analysis, LUS on days 3–4 and day 7 accurately predicted BPD (day 3–4 OR (95% CI)=1.54 (1.03 to 2.42), p=0.044; day 7 OR (95% CI)=1.66 (1.07 to 2.70), p=0.031). The predictive value of LUS was insignificant in a multivariate model in which gestational age was the dominant predictor. LUS accurately predicted interim respiratory outcomes including surfactant administration, duration of intubation and extubation to non-invasive support at 48 hours.ConclusionsLUS in the first week of life predicted BPD. However, LUS offers little additive accuracy to current gestational age-based models.Trial registration numberACTRN12617000208303. |
| Databáze: | OpenAIRE |
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