Sublethal sperm freezing damage: Manifestations and solutions
| Autor: | Taylor Pini, Simon P. de Graaf, T. Leahy |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Semen Biology Cryopreservation 03 medical and health sciences Cryoprotective Agents 0302 clinical medicine Immune system Food Animals Animals Humans Small Animals Fallopian Tubes Sperm-Ovum Interactions chemistry.chemical_classification Reactive oxygen species 030219 obstetrics & reproductive medicine Equine 0402 animal and dairy science Genitalia Female 04 agricultural and veterinary sciences Spermatozoa 040201 dairy & animal science Sperm Semen cryopreservation Mucus Sexual reproduction Cell biology Fertility chemistry Female Animal Science and Zoology Reactive Oxygen Species Sperm Capacitation Semen Preservation |
| Zdroj: | Theriogenology. 118:172-181 |
| ISSN: | 0093-691X |
| DOI: | 10.1016/j.theriogenology.2018.06.006 |
| Popis: | Semen cryopreservation is an important tool for artificial breeding, species conservation and human reproductive medicine. However, sublethal freezing damage remains an important limitation of the cryopreservation process, inevitably leading to reduced fertility in vivo. This review explores several facets of sublethal freezing damage, touching on cryocapacitation, the generation of reactive oxygen species and alterations to sperm proteins, lipids and sugars. The effects of sublethal freezing damage on sperm performance in vivo are also discussed, examining fertile lifespan and interaction with female reproductive tract immune cells, mucus and oviductal cells. Finally, the cryoprotective potential of whole seminal plasma and individual proteins are explored. |
| Databáze: | OpenAIRE |
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