Herbal Combinational Medication of Glycyrrhiza glabra, Agastache rugosa Containing Glycyrrhizic Acid, Tilianin Inhibits Neutrophilic Lung Inflammation by Affecting CXCL2, Interleukin-17/STAT3 Signal Pathways in a Murine Model of COPD
| Autor: | Jung-Hee Hong, Jeong-Ho Geum, Hye-Rim Kim, Won-Kyung Yang, Seung-Hyung Kim, Yun-Mi Kang, Su-Young Choi, Hyo-Jin An, Young-Cheol Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Chronic bronchitis Agastacha rugosa Agastache Chemokine CXCL2 Pharmacology Polymerase Chain Reaction STAT3 Mice Pulmonary Disease Chronic Obstructive 0302 clinical medicine Glycosides Lung Mice Inbred BALB C Nutrition and Dietetics biology medicine.diagnostic_test Chemistry Interleukin-17 respiratory system CXCL-2 CXCL2 IL-17 030220 oncology & carcinogenesis Interleukin 17 lcsh:Nutrition. Foods and food supply Signal Transduction STAT3 Transcription Factor Glycyrrhiza glabra lcsh:TX341-641 Lung injury complex mixtures Article Proinflammatory cytokine 03 medical and health sciences medicine Glycyrrhiza Animals COPD Flavonoids Plant Extracts Pneumonia biology.organism_classification Glycyrrhizic Acid Agastache rugosa respiratory tract diseases Disease Models Animal 030104 developmental biology Bronchoalveolar lavage Food Science |
| Zdroj: | Nutrients Volume 12 Issue 4 Nutrients, Vol 12, Iss 926, p 926 (2020) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12040926 |
| Popis: | Chronic obstructive pulmonary disease (COPD) is caused by exposure to toxic particles, such as coal fly ash (CFA), diesel-exhaust particle (DEP), and cigarette smoke (CS), leading to chronic bronchitis, mucus production, and a subsequent lung dysfunction. This study, using a mouse model of COPD, aimed to evaluate the effect of herbal combinational medication of Glycyrrhiza glabra (GG), Agastache rugosa (AR) containing glycyrrhizic acid (GA), and tilianin (TN) as active ingredients. GA, a major active component of GG, possesses a range of pharmacological and biological activities including anti-inflammatory, anti-allergic, anti-oxidative. TN is a major flavonoid that is present in AR. It has been reported to have anti-inflammatory effects of potential utility as an anti-COPD agent. The COPD in the mice model was induced by a challenge with CFA and DEP. BALB/c mice received CFA and DEP alternately three times for 2 weeks to induce COPD. The herbal mixture of GG, AR, and TN significantly decreased the number of neutrophils in the lungs and bronchoalveolar lavage (BAL) fluid. It also significantly reduced the production of C-X-C motif chemokine ligand 2 (CXCL-2), IL-17A, CXCL-1, TNF-&alpha symmetric dimethylarginine (SDMA) in BALF and CXCL-2, IL-17A, CXCL-1, MUC5AC, transient receptor potential vanilloid-1 (TRPV1), IL-6, COX-2, NOS-II, and TNF-&alpha mRNA expression in the lung tissue. Notably, a combination of GG and AR was more effective at regulating such therapeutic targets than GG or AR alone. The histolopathological lung injury was alleviated by treatment with the herbal mixture and their active ingredients (especially TN). In this study, the herbal combinational mixture more effectively inhibited neutrophilic airway inflammation by regulating the expression of inflammatory cytokines and CXCL-2 by blocking the IL-17/STAT3 pathway. Therefore, a herbal mixture of GG and AR may be a potential therapeutic agent to treat COPD. |
| Databáze: | OpenAIRE |
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