A Comparison of Nucleotide Sequences of Measles Virus L Genes Derived from Wild-Type Viruses and SSPE Brain Tissues
| Autor: | I. Pardowitz, Martin A. Billeter, K. Baczko, V ter Meulen, K. Komase, Bertus K. Rima, C. Kunz |
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| Rok vydání: | 1995 |
| Předmět: |
Genes
Viral Sequence analysis Measles Vaccine Molecular Sequence Data Virus Measles virus chemistry.chemical_compound Virology Humans Amino Acid Sequence Cloning Molecular Child Peptide sequence Gene Phylogeny Viral Structural Proteins Genetics Base Sequence biology Wild type Brain Genetic Variation virus diseases Sequence Analysis DNA biology.organism_classification Open reading frame chemistry SSPE Virus Mutation Female Subacute Sclerosing Panencephalitis DNA |
| Zdroj: | Virology. 208:795-799 |
| ISSN: | 0042-6822 |
| Popis: | The nucleotide sequences of the large protein (L) gene derived from two wild-type measles viruses (MV) and two SSPE brain-derived viruses have been determined. All sequences have single large open reading frames encoding 2183 amino acid residues. The deduced L proteins are well conserved and the proposed functional domains which have been identified for rhabdo- and paramyxoviruses are completely conserved in all strains. The degree of variability of L proteins is the lowest of all structural proteins of MV, reflecting its role in virus reproduction and persistence. Biased hypermutation was not observed in the L genes derived from SSPE brain tissue. None of the nucleotide changes can be associated with the attenuated phenotype of the Edmonston vaccine viruses. |
| Databáze: | OpenAIRE |
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