Risk factors of Clostridium difficile-associated diarrhea in hospitalized adults: Vary by hospitalized duration
| Autor: | Hsiu Chuan Liu, Yuan Pin Hung, Hsiao Ju Lin, Pei Jane Tsai, Jen Chieh Lee, Jia Ling Wu, Hsiao Chieh Liu, Wen Chien Ko, Bo Yang Tsai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Proton pump inhibitors 0302 clinical medicine Diabetes mellitus Risk Factors Neoplasms Odds Ratio Immunology and Allergy Prospective Studies 030212 general & internal medicine Aged 80 and over Cross Infection General Medicine Middle Aged Clostridium difficile QR1-502 Anti-Bacterial Agents Hospitalization Diarrhea Infectious Diseases Female medicine.symptom Adult Microbiology (medical) Clostridium difficile associated diarrhea medicine.medical_specialty medicine.drug_class 030106 microbiology Cephalosporin Taiwan Proton-pump inhibitor Malignancy Microbiology 03 medical and health sciences Internal medicine medicine Humans Prolonged hospitalization Aged General Immunology and Microbiology Clostridioides difficile business.industry Odds ratio medicine.disease bacterial infections and mycoses Confidence interval Cephalosporins Logistic Models Clostridium Infections business |
| Zdroj: | Journal of Microbiology, Immunology and Infection, Vol 54, Iss 2, Pp 276-283 (2021) |
| ISSN: | 1684-1182 |
| Popis: | Background Clostridium difficile is the leading cause of nosocomial infectious diarrhea. Hospitalized patients were at risk of C. difficile-associated diarrhea (CDAD). However the risk factors of CDAD in patients with different hospitalization period are not clear. Material and methods A prospective investigation was conducted in medical wards of a district hospital in southern Taiwan, from January 2011 to January 2013. We arbitrary divided patients into two groups: hospitalized for at most 14 days and 15–30 days, and analyzed their risk factors for CDAD. Results Overall 451 patients were enrolled. The multivariable analysis of 19 (8.0%) patients developing CDAD within 14 days' hospital stay and 216 patients hospitalized for ≤ 14 days without CDAD showed malignancy (odds ratio [OR] 7.15, 95% confidence interval [CI] 1.82–28.09; P = 0.005), prior cephalosporin (OR 10.8, 95% CI 1.3–93.9; P = 0.03) and proton pump inhibitor (PPI; OR 7.1, 95% CI 2.1–24.7; P = 0.002) therapy were independently related to CDAD (Table 3), but hypertension (OR 0.2, 95% CI 0.1–0.7; P = 0.01) was reversely related to CDAD. However, of 9 (4.2%) patients developing CDAD later (15–30 days' hospital stay) and 207 patients with longer hospitalization (15–30 days) but free of CDAD, malignancy (OR 14.0, 95% CI 1.6–124.9; P = 0.02) and underlying diabetes mellitus (OR 20.5, 95% CI 2.9–144.9; P = 0.002) were independent risk factors of CDAD. Conclusion Risk factors for CDAD among hospitalized patients varied by the duration of hospital stay. Intervention strategies to prevent CDAD may be different in terms of hospital stay duration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|