In quest of optimal drug-supported and targeted bone regeneration in the cranio facial area: a review of techniques and methods

Autor:	Alexandru R. Biris, Mihaela Hedesiu, Ondine Lucaciu, Radu Septimiu Campian, Noemi Dirzu, Liana Crisan, Winfried Kretschmer, Bogdan Crisan, Grigore Baciut, Lucia Hurubeanu, Mihaela Baciut, Olga Soritau, Sergiu Vacaras, Simion Bran
Rok vydání:	2015
Předmět:	medicine.medical_specialty Bone Regeneration Degeneration (medical) Bone Infection Drug Delivery Systems Atrophy Animals Humans Medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Craniofacial Bone regeneration Bone Transplantation Tissue Engineering Tissue Scaffolds business.industry Stem Cells Skull Cell Differentiation medicine.disease Surgery medicine.anatomical_structure Targeted drug delivery Stem cell business
Zdroj:	Drug Metabolism Reviews. 47:455-469
ISSN:	1097-9883 0360-2532
DOI:	10.3109/03602532.2015.1124889
Popis:	Craniofacial bone structures are frequently and extensively affected by trauma, tumors, bone infections and diseases, age-related degeneration and atrophy, as well as congenital malformations and developmental anomalies. Consequently, severe encumbrances are imposed on both patients and healthcare systems due to the complex and lengthy treatment duration. The search for alternative methods to bone transplantation, grafting and the use of homologous or heterologous bone thus responds to one of the most significant problems in human medicine. This review focuses on the current consensus of bone-tissue engineering in the craniofacial area with emphasis on drug-induced stem cell differentiation and induced bone regeneration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff3259a0e046f55198883e0caae1a80 https://doi.org/10.3109/03602532.2015.1124889 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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