The Association of Ménétrier Disease with Ulcerative Colitis: A Case Report with Implications on the Pathogenesis of Ménétrier Disease
Autor: | Cuong C. Nguyen, Alvin C. Silva, Vien X. Nguyen, Giovanni De Petris, Jacques Heppell, Jonathan A. Leighton, Shabana F. Pasha |
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Jazyk: | angličtina |
Rok vydání: | 2010 |
Předmět: |
medicine.medical_specialty
TGF alpha Pathology Menetrier disease Transforming growth factor-alpha Cetuximab Gastroenterology Pathogenesis Internal medicine medicine Gastric mucosa Ménétrier disease Epidermal growth factor receptor lcsh:RC799-869 biology business.industry Stomach medicine.disease Ulcerative colitis digestive system diseases Published: February 2010 medicine.anatomical_structure biology.protein lcsh:Diseases of the digestive system. Gastroenterology business medicine.drug |
Zdroj: | Case Reports in Gastroenterology, Vol 4, Iss 1, Pp 66-70 (2010) Case Reports in Gastroenterology |
ISSN: | 1662-0631 |
Popis: | Ménétrier disease (MD) is a rare hypertrophic condition of the gastric mucosa. The unusual association of MD with ulcerative colitis (UC) has been reported in the literature in eight cases. Transforming growth factor-alpha (TGF-alpha) is overexpressed in UC and appears to play a role in colonic healing and repair. Overproduction of TGF-alpha in murine stomach has been shown to induce gastric hypertrophy similar to MD. It can be hypothesized that increased expression of TGF-alpha may occur in the gastric mucosa in patients with UC and may lead to MD. We report the ninth case of MD associated with UC. The role of TGF-alpha and treatment with cetuximab are discussed. |
Databáze: | OpenAIRE |
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