LONGITUDINAL CHANGE IN COGNITIVE FLEXIBILITY: IMPACT OF AGE, HYPERTENSION, AND APOE4
Autor: | J Blaskewicz Boron, Sherry L. Willis, K. Schaie, Paul Robinson, Wonjeong Haavisto |
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Rok vydání: | 2018 |
Předmět: | |
Zdroj: | Innovation in Aging. 2:249-249 |
ISSN: | 2399-5300 |
DOI: | 10.1093/geroni/igy023.929 |
Popis: | Higher cognitive flexibility is positively associated with adapting to changes during aging. Those more flexible tend to have higher cognitive scores. Maintenance of cognitive functioning and living independently are important goals; determining risk factors of non-normative change is imperative. Using multivariate multilevel modeling, we examined the impact of age, hypertension, and presence of APOEe4 allele on longitudinal change in cognitive flexibility in 1024 participants from the Seattle Longitudinal Study (baseline mean age= 51.9; mean education=13.9; 52.6% female; 26.9% APOEe4; 62% hypertensive). The Test of Behavioral Rigidity yielded three factors: motor cognitive flexibility (MCR), attitudinal flexibility (PPR), and psychomotor speed (PPS). Cognitive flexibility has been characterized in terms of personality; MCR is associated with executive function; PPS is indicative of perceptual speed; PPR is related to attitudinal adaptation to environmental change. Rate of decline increased with age for all three factors (MCR, p< .01; PPS, p< .01; PPR, p < .01). APOE e4 allele resulted a steeper rate of decline for MCR (p< .01) and PPS (p< .01). The APOE e4 allele is a major genetic risk factor for dementia, and has been related to executive function and frontal brain atrophy. Presence of hypertension resulted in steeper rate of decline for PPR (p |
Databáze: | OpenAIRE |
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