INHIBITION OF 3-BETA-HYDROXY STEROID DEHYDROGENASE ACTIVITY IN FIRST TRIMESTER HUMAN PREGNANCY WITH TRILOSTANE AND WIN 32729
| Autor: | B. Piura, Z. M. Spuy, V.H.T. James, D. B. Paintin, D. L. Jones, Howard S. Jacobs, C. S. W. Wright |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
3-Hydroxysteroid Dehydrogenases Hydrocortisone Endocrinology Diabetes and Metabolism Population Dehydroepiandrosterone Trilostane Biology Steroid dehydrogenase activity Pharmacology Epostane chemistry.chemical_compound Endocrinology Pregnancy Internal medicine medicine Humans education Progesterone education.field_of_study Abortifacient Agents Dose-Response Relationship Drug Abortifacient Agents Steroidal Dihydrotestosterone Progesterone secretion Pregnancy Trimester First chemistry Pregnenolone Female medicine.drug Hormone |
| Zdroj: | Clinical Endocrinology. 19:521-532 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.1983.tb00027.x |
| Popis: | The effects of equivalent doses of 2 inhibitors of the 3-beta-hdyroxy steroid dehydrogenase enzyme system--WIN 24540 (trilostane) and WIN 32729--on the secretion of progesterone in early human pregnancy are described. Patients and controls less than 12 weeks pregnant were given a single dose of either drug and the resultant hormonal changes monitored for 7 1/2 hours. A consistent fall in plasma progesterone concentrations occurred at all dose levels and at the highest dose they fell to less than 50% of pretreatment levels. However while with trilostane the associated increase in plasma concentrations of pregnenolone was always accompanied by a rise in plasma DHA concentrations with WIN 32729 there appeared to be adrenal effect at the lower dosage levels. These data demonstrate inhibition of progesterone secretion in human pregnancy using nonhormonally active steroids. The pattern of steroid precursors indicates that while both drugs inhibit 3-beta-hydroxy steroid dehyrogenase activity WIN 32729 is more selective and only interferes with adrenal steroid biosynthesis at high doses. (authors) |
| Databáze: | OpenAIRE |
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