Association of human papillomavirus and bacterial vaginosis with increased risk of high-grade squamous intraepithelial cervical lesions
| Autor: | Edilson Damke, Raquel P. Souza, Fabrícia Gimenes, Vânia Ramos Sela da Silva, Nelson Shozo Uchimura, Natália Malaguti, Marcia Edilaine Lopes Consolaro, Tamy T Suehiro |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Population Cervical intraepithelial neoplasia Malignancy medicine.disease_cause Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Cytology medicine Gardnerella vaginalis education Cervix 030304 developmental biology Cervical cancer 0303 health sciences education.field_of_study business.industry Obstetrics and Gynecology medicine.disease medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Bacterial vaginosis business |
| Zdroj: | International Journal of Gynecologic Cancer. 29:242-249 |
| ISSN: | 1525-1438 1048-891X |
| DOI: | 10.1136/ijgc-2018-000076 |
| Popis: | ObjectiveTo assess the rates of co-infections between human papillomavirus (HPV) and 13 key markers of bacterial vaginosis in cervical samples by multiplex polymerase chain reaction in a population with a high rate of abnormal cytology and a positive HPV test.MethodsThe study included a total of 213 women aged 18–72 years screened using Papanicolaou smears for determining cervical abnormalities and for HPV and bacterial vaginosis by single-target and multiplex polymerase chain reaction.ResultsA total of 83 (39%) women were negative for intraepithelial lesion or malignancy cytology and 130 (61%) had abnormal cytology. HPV-DNA prevalence was 69.9% and bacterial vaginosis was 72.7 %. Co-infections between bacterial vaginosis with HPV-DNA and high-risk HPV were associated with an increased risk for squamous intraepithelial lesions of low-grade cytology and high-grade squamous intraepithelial lesions plus cervical cancer. The most frequent bacterial vaginosis agent was Gardnerella vaginalis (33.8%), and co-infection with HPV-DNA and high-risk HPV increased the risk for squamous intraepithelial lesions of low grade cytology and high-grade squamous intraepithelial lesions plus cervical cancer. Co-infection between Megasphaera type I and high-risk HPV increased the risk for high-grade squamous intraepithelial lesions plus cervical cancer.ConclusionsOur results reinforce the hypothesis that some bacterial vaginosis agents may play a role as co-factors in HPV-mediated cervical carcinogenesis, at least in some populations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|