Sporothrix brasiliensis: A Review of an Emerging South American Fungal Pathogen, Its Related Disease, Presentation and Spread in Argentina
| Autor: | Miguel Scarpa, Javier Mas, C. Iovannitti, Alejandro Etchecopaz, María Agustina Toscanini, Amelia Gisbert, Karla Bendezú, María Luján Cuestas, Ricardo Iachini, Alejandro D. Nusblat |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
diagnosis virulence factors Argentina Virulence Review Plant Science Disease 03 medical and health sciences Sporothrix brasiliensis medicine Sporothrix schenckii cat-transmitted sporotrichosis lcsh:QH301-705.5 Ecology Evolution Behavior and Systematics Mycosis 030304 developmental biology therapy 0303 health sciences biology Sporotrichosis 030306 microbiology Transmission (medicine) Zoonosis Outbreak zoonosis vaccines medicine.disease biology.organism_classification Virology lcsh:Biology (General) |
| Zdroj: | Journal of Fungi Journal of Fungi, Vol 7, Iss 170, p 170 (2021) |
| ISSN: | 2309-608X |
| DOI: | 10.3390/jof7030170 |
| Popis: | Sporotrichosis, caused by Sporothrix schenckii and related species, is the most frequent implantation mycosis in Latin America. In Argentina, over the last 8 years, there have been 0.16 new cases per month of feline sporotrichosis in 2011, increasing to 0.75 cases per month in 2019 and involving zoonotic transmission to humans. Molecular identification by polymerase chain reaction (PCR) detected Sporothrix brasiliensis in these feline and zoonotic outbreaks. This study will focus on different feline and human sporotrichosis outbreaks caused by S. brasiliensis in Argentina during 2011–2019. We will address the sources of infection and environmental hotspots, as well as the application of several treatment strategies for improving the pharmacotherapy of the different clinical forms of the disease. Finally, we will provide a detailed summary of the clinical aspects and new advances in host–pathogen interactions, virulence factors and immune response, focusing on state-of-the-art diagnostic tools and potential vaccine candidates. |
| Databáze: | OpenAIRE |
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