Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances
| Autor: | Erind Gjermeni, Ulrich Laufs, Diana Le Duc, Matthias Blüher, Antje Garten, Linnaeus Bundalian, Anna Kirstein, Michael Kirchhof, Florentien Kolbig, Julius L. Katzmann |
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| Rok vydání: | 2021 |
| Předmět: |
obesity
Anti-obesity Drugs Diabetes Mellitus Energy Balance Obesity Obesity Metabolism anti-obesity drugs Review Fat absorption Bioinformatics Microbiology Biochemistry Pharmacotherapy Intersection Risk Factors Orexigenic Diabetes mellitus medicine Humans Molecular Biology business.industry medicine.disease Gut hormones energy balance QR1-502 Pathophysiology obesity metabolism diabetes mellitus Anti-Obesity Agents Energy Metabolism business medicine.drug |
| Zdroj: | Biomolecules 11:1426 (2021) Biomolecules Biomolecules, Vol 11, Iss 1426, p 1426 (2021) |
| ISSN: | 2218-273X |
| DOI: | 10.3390/biom11101426 |
| Popis: | Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat absorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored. |
| Databáze: | OpenAIRE |
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