Piperacillin versus cefotetan as single-dose prophylaxis in abdominal hysterectomy: a prospective, randomized, multicenter study
| Autor: | V. Meregalli, F. Quaglia, Rodolfo Milani, L. Negri, L. Archetti, F. Rampinelli, L. Doregatti, E. Demaria, R. Conturso, G. Alegente, Gc. Zanella, F. De Lalla, F. Pollini, S. Scalambrino, A. Tramarin, Pg. Tassi, A. Lojacono, R Nicolin |
|---|---|
| Přispěvatelé: | Delalla, F, Tassi, P, Conturso, R, Archetti, L, Zanella, G, Meregalli, V, Milani, R, Quaglia, F, Nicolin, R, Scalambrino, S, Alegente, G, Doregatti, L, Pollini, F, Demaria, E, Negri, L, Rampinelli, F, Lojacono, A, Tramarin, A |
| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Cefotetan medicine.medical_treatment Premedication Antibiotics Uterus 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Hysterectomy 03 medical and health sciences 0302 clinical medicine medicine Humans Surgical Wound Infection Pharmacology (medical) Prospective Studies Prophylaxi Pharmacology Piperacillin Chemotherapy Abdominal hysterectomy business.industry Middle Aged medicine.disease Surgery Infectious Diseases medicine.anatomical_structure Oncology Anesthesia Bacteremia Female business medicine.drug Subcutaneous tissue |
| Zdroj: | Journal of chemotherapy (Florence, Italy). 5(2) |
| ISSN: | 1120-009X |
| Popis: | ive hundred and sixty-six women, consecutively admitted to nine different hospitals for elective abdominal hysterectomy, were randomized to receive a single 2 g i.v. dose of either cefotetan or piperacillin at induction of anesthesia. Five patients were excluded and 561 (287 given cefotetan and 274 given piperacillin) could be evaluated. In 10 patients (5 for each drug) the concentrations of either cefotetan or piperacillin in serum and subcutaneous tissue at the beginning and at the end of surgery andin uterus, salpinx and ovary samples, were microbiologically assessed. Adverse events to prophylactic drugs were never observed. No significant differences could be found between cefotetan and piperacilin groups for any of the considered infectious complications (bacteremia, wound or vaginal cuff infection, pelvic cellulitis and febrile morbidity) nor for the pooled data (cefotetan group: 4.9%, piperacillin group: 5.8%, p:NS). As for the concentrations of prophylactic drugs, serum levels throughout surgery were found to be adequate |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|