Longitudinal diffusion changes in celebral hemispheres after MCA infarcts
| Autor: | Denis Le Bihan, Hugues Chabriat, Marie-Germaine Bousser, Nicolas Molko, Dominique Hervé, Isabelle Denghien, F. Buffon, Raphaël Porcher, Sabina Pappatà |
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| Přispěvatelé: | Transduction du Signal et Plasticite Dans Le Systeme Nerveux, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département d'épidémiologie, biostatistique et recherche clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biostatistique et épidémiologie clinique, Institut National de la Santé et de la Recherche Médicale (INSERM), Biostatistique et épidemiologie clinique, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Human Brain Research Center [Kyoto] (HBRC), Kyoto University [Kyoto], Service Hospitalier Frédéric Joliot (SHFJ), Service de neurologie [Univ. Paris VII], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Kyoto University, Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Telencephalon Time Factors [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging MESH: Diffusion Magnetic Resonance Imaging computer.software_genre Statistical parametric mapping Functional Laterality 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance Voxel medicine.artery Fractional anisotropy Image Processing Computer-Assisted medicine Humans MESH: Functional Laterality Diaschisis Aged MESH: Aged MESH: Humans MESH: Middle Aged Cerebral infarction business.industry MESH: Time Factors MESH: Infarction Middle Cerebral Artery Infarction Middle Cerebral Artery MESH: Adult Middle Aged medicine.disease MESH: Image Processing Computer-Assisted Radiography Diffusion Magnetic Resonance Imaging Neurology nervous system Middle cerebral artery Cerebral hemisphere MESH: Telencephalon Disease Progression MESH: Disease Progression Neurology (clinical) Cardiology and Cardiovascular Medicine business computer Neuroscience 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Journal of cerebral blood flow and metabolism 25 (2005): 641–650. doi:10.1038/sj.jcbfm.9600054 info:cnr-pdr/source/autori:Buffon F; Molko N; Herve D; Porcher R; Denghien I; Pappata' S; Le Bihan D; Bousser MG; Chabriat H;/titolo:Longitudinal diffusion changes in celebral hemispheres after MCA infarcts/doi:10.1038%2Fsj.jcbfm.9600054/rivista:Journal of cerebral blood flow and metabolism/anno:2005/pagina_da:641/pagina_a:650/intervallo_pagine:641–650/volume:25 Journal of Cerebral Blood Flow and Metabolism Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2005, 25 (5), pp.641-50. ⟨10.1038/sj.jcbfm.9600054⟩ Journal of Cerebral Blood Flow and Metabolism, 2005, 25 (5), pp.641-50. ⟨10.1038/sj.jcbfm.9600054⟩ |
| ISSN: | 0271-678X 1559-7016 |
| DOI: | 10.1038/sj.jcbfm.9600054 |
| Popis: | International audience; Diffusion tensor imaging can be used in vivo to assess the longitudinal and regional microstructural changes occurring after middle cerebral artery (MCA) infarcts in humans. Nine patients were investigated 1 week (D7), 1 (M1), 3 (M3), and 6 months (M6) after the occurrence of an isolated MCA infarction. First, an overall analysis was performed using histograms of mean diffusivity (MD) and fractional anisotropy (FA) in each hemisphere. Thereafter, the regional pattern of diffusion changes was investigated voxel by voxel with statistical parametric mapping 99. In the hemisphere ipsilateral to the infarction, histogram analysis revealed a significant decrease in FA between D7 and M6 associated with a progressive increase in MD from D7 to M3. Remote from the MCA territory, the voxel by voxel analyses detected a significant increase in MD within the thalamus at M3 and M6 and a reduction in FA along the pyramidal tract at M6. In the contralateral hemisphere, between D7 and M6, a significant hemispheric atrophy was observed in association with a global reduction in anisotropy, in the absence of distinctive regional diffusion changes. These results suggest that micro- and macrostructural tissue modifications can be detected with diffusion tensor imaging in regions remote from the ischemic area in both hemispheres. |
| Databáze: | OpenAIRE |
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