A behavioural and pharmacological evaluation of the discriminative stimulus induced by pentylenetetrazole in the pig
| Autor: | J. P. Fry, M. P. Carey |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Conditioned emotional response Reinforcement Schedule Swine medicine.drug_class medicine.medical_treatment Emotions Stimulus (physiology) Pharmacology Discrimination Psychological medicine Animals Electroshock Benzodiazepine Diazepam Behavior Animal Anticonvulsant Ethosuximide Anxiogenic Anesthesia Conditioning Operant Pentylenetetrazole Cues Psychology Stimulus control medicine.drug |
| Zdroj: | Psychopharmacology. 111:244-250 |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | The anxiogenic nature of the interoceptive discriminative stimulus induced by pentylenetetrazole (PTZ) was investigated by examining the discriminatory behaviour of PTZ conditioned pigs during a conditioned emotional response (CER). A CER was induced in a nonoperant situation, by pairing a tone stimulus with the application of a mild, non-injurious electric shock. Subsequent presentation of the conditioned tone stimulus alone produced a generalisation to the PTZ cue. This generalisation of the conditioned emotional state (CES) to the PTZ cue was antagonised by pretreatment with diazepam (0.5 mg/kg, PO; 30 min). The PTZ stimulus was also antagonised by diazepam (0.5 mg/kg, PO; 30 min) but not by an anticonvulsant dose of ethosuximide (30 mg/kg, PO; 1-3 h), providing further confirmation of the anxiogenic nature of the PTZ cue. Our results demonstrate the validity of the PTZ discrimination paradigm in pigs as a test of anxiety. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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