Delusional and psychotic disorders in juvenile myotonic dystrophy type-1

Autor: Jean Steyaert, D Willekens, Christine E. M. de Die-Smulders, Jean-Pierre Frijns, Delphine Jacobs
Přispěvatelé: RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: DA KG Polikliniek (9), Klinische Genetica
Rok vydání: 2017
Předmět:
Male
CBCL
PHENOTYPE
MYOPATHY
0302 clinical medicine
Myotonic Dystrophy
Medicine
Genetics (clinical)
Depression (differential diagnoses)
Genetics & Heredity
Psychiatry
Delusional disorder
juvenile myotonic disorder
Not Otherwise Specified
EXPANSION
Prognosis
delusional disorder
DEPRESSION
Psychiatry and Mental health
Female
Psychiatric interview
medicine.symptom
Life Sciences & Biomedicine
Adult
muscular dystrophy
medicine.medical_specialty
Adolescent
CHILDHOOD TYPE
PROFILE
Myotonic dystrophy
Delusions
Young Adult
03 medical and health sciences
Cellular and Molecular Neuroscience
Humans
Juvenile
Psychiatric Status Rating Scales
Science & Technology
PERSONALITY-PATTERNS
business.industry
Thought disorder
psychotic disorder
medicine.disease
GENE
MUSCULAR-DYSTROPHY
030227 psychiatry
Philosophy
Psychotic Disorders
UNSTABLE CTG REPEAT
psychosocial functioning
Human medicine
business
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: American journal of medical genetics: part B: neuropsychiatric genetics
American Journal of Medical Genetics Part B-neuropsychiatric Genetics, 174(4), 359-366. Wiley
ISSN: 1552-4841
DOI: 10.1002/ajmg.b.32524
Popis: We investigated the clinically derived hypothesis of a relatively high incidence of delusional and psychotic disorders in adolescents with juvenile Myotonic Dystrophy type-1 (DM1). Twenty-seven subjects of age 16-25 with juvenile DM1 and their parents were invited to have a clinical psychiatric interview, and to complete an ASEBA behavior checklist (YSR, ASR, CBCL, and ABCL). We diagnosed a Delusional Disorder in 19% of our patients and a Psychotic Disorder not otherwise specified in another 19%. These two groups of patients had a significantly worse level of clinically defined general functioning. It is clinically relevant to investigate in patients with juvenile DM the symptom of delusions and the presence of a delusional and psychotic disorder, and to consider the presence of juvenile DM in youngsters presenting with such a thought disorder. These disorders compromise the general functioning of the subjects and are often to some extent treatable. © 2017 Wiley Periodicals, Inc. ispartof: American Journal of Medical Genetics B, Neuropsychiatric Genetics vol:174 issue:4 pages:359-366 ispartof: location:United States status: published
Databáze: OpenAIRE
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