On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis
| Autor: | Michael A. Castello, Salvador Soriano |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Aging
Time Factors Amyloid Amyloid beta Regulator Late onset Plaque Amyloid Disease Biochemistry Pathogenesis Amyloid beta-Protein Precursor Alzheimer Disease Risk Factors medicine Animals Humans Genetic Predisposition to Disease Molecular Biology Amyloid beta-Peptides biology Neurodegeneration Brain medicine.disease Biochemistry of Alzheimer's disease Phenotype Neurology Nerve Degeneration biology.protein Disease Progression Psychology Neuroscience Biotechnology |
| Zdroj: | Ageing research reviews. 13 |
| ISSN: | 1872-9649 |
| Popis: | The amyloid cascade hypothesis, which implicates the amyloid Aβ peptide as the pathological initiator of both familial and sporadic, late onset Alzheimer's disease (AD), continues to guide the majority of research. We believe that current evidence does not support the amyloid cascade hypothesis for late onset AD. Instead, we propose that Aβ is a key regulator of brain homeostasis. During AD, while Aβ accumulation may occur in the long term in parallel with disease progression, it does not contribute to primary pathogenesis. This view predicts that amyloid-centric therapies will continue to fail, and that progress in developing successful alternative therapies for AD will be slow until closer attention is paid to understanding the physiological function of Aβ and its precursor protein. |
| Databáze: | OpenAIRE |
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