Angiotensin II analogs comprised of Pro-Amb (γ-turn scaffold) as angiotensin II type 2 (AT(2)) receptor agonists
| Autor: | Ganesh S. Jedhe, Santosh Pasha, Gangadhar J. Sanjayan, Amol S. Kotmale, Pattuparambil R. Rajamohanan |
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| Rok vydání: | 2015 |
| Předmět: |
Scaffold
Angiotensin receptor Aqueous solution 010405 organic chemistry Chemistry Angiotensin II Metals and Alloys General Chemistry 010402 general chemistry 01 natural sciences Receptor Angiotensin Type 2 Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Cell Line Turn (biochemistry) Biochemistry Materials Chemistry Ceramics and Composites Humans Receptor |
| Zdroj: | Chemical communications (Cambridge, England). 52(8) |
| ISSN: | 1364-548X |
| Popis: | We describe herein the design, synthesis and conformational investigation of Pro-Amb (proline-3-amino-2-methoxybenzoic acid) incorporated Angiotensin II and its truncated analogues. Solution-state NMR and CD studies suggest γ-turn-like conformation in Pro-Amb analogs in aqueous solution. Furthermore, Pro-Amb analogs have been shown to act as AT2 receptor agonists. |
| Databáze: | OpenAIRE |
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