Prooxidant/Antioxidant Balance in Hypoxia: A Cross-Over Study on Normobaric vs. Hypobaric 'Live High-Train Low'
| Autor: | Vincent Pialoux, Pauline Mury, Tadej Debevec, Grégoire P. Millet, Laurent Schmitt, Raphael Faiss, Roberto Cejuela, Sabine Ehrström, Jonas Saugy |
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| Přispěvatelé: | Universidad de Alicante. Departamento de Didáctica General y Didácticas Específicas, Grupo de Investigación en Ciencias de la Actividad Física y el Deporte (GICAFD), Jozef Stefan Institute [Ljubljana] (IJS), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université de Lausanne (UNIL) |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant Hypobaric [SDV]Life Sciences [q-bio] medicine.medical_treatment lcsh:Medicine medicine.disease_cause Superoxide dismutase Normobaric chemistry.chemical_compound Internal medicine Blood plasma Educación Física y Deportiva medicine Humans Hypoxia lcsh:Science ComputingMilieux_MISCELLANEOUS Multidisciplinary biology Superoxide Dismutase Chemistry Nitrotyrosine lcsh:R Live High-Train Low Hypoxia (medical) Uric Acid Oxidative Stress Prooxidant/Antioxidant Balance Endocrinology Advanced Oxidation Protein Products Physical Fitness Catalase Immunology biology.protein Tyrosine Uric acid lcsh:Q Advanced Oxidation Protein Products/blood Anoxia/blood Superoxide Dismutase/blood Tyrosine/analogs & derivatives Tyrosine/blood Uric Acid/blood medicine.symptom Oxidative stress Research Article |
| Zdroj: | PLoS ONE, Vol 10, Iss 9, p e0137957 (2015) RUA. Repositorio Institucional de la Universidad de Alicante Universidad de Alicante (UA) PLoS ONE PLoS ONE, Public Library of Science, 2015, 10 (9), ⟨10.1371/journal.pone.0137957⟩ Plos One, vol. 10, no. 9, pp. e0137957 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0137957 |
| Popis: | “Live High-Train Low” (LHTL) training can alter oxidative status of athletes. This study compared prooxidant/antioxidant balance responses following two LHTL protocols of the same duration and at the same living altitude of 2250 m in either normobaric (NH) or hypobaric (HH) hypoxia. Twenty-four well-trained triathletes underwent the following two 18-day LHTL protocols in a cross-over and randomized manner: Living altitude (PIO2 = 111.9 ± 0.6 vs. 111.6 ± 0.6 mmHg in NH and HH, respectively); training “natural” altitude (~1000–1100 m) and training loads were precisely matched between both LHTL protocols. Plasma levels of oxidative stress [advanced oxidation protein products (AOPP) and nitrotyrosine] and antioxidant markers [ferric-reducing antioxidant power (FRAP), superoxide dismutase (SOD) and catalase], NO metabolism end-products (NOx) and uric acid (UA) were determined before (Pre) and after (Post) the LHTL. Cumulative hypoxic exposure was lower during the NH (229 ± 6 hrs.) compared to the HH (310 ± 4 hrs.; P |
| Databáze: | OpenAIRE |
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