Motor-protein 'roundabouts': microtubules moving on kinesin-coated tracks through engineered networks
| Autor: | Viola Vogel, Henry Hess, Carolyn M. Matzke, Robert K. Doot, George D. Bachand, John Clemmens |
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| Rok vydání: | 2004 |
| Předmět: |
Engineering
business.industry Track (disk drive) Escherichia coli Proteins Molecular Motor Proteins Biomedical Engineering Kinesins Bioengineering Nanotechnology General Chemistry Biochemistry Microtubules Motor protein Drosophila melanogaster Microtubule Molecular motor Kinesin Animals Drosophila Proteins Sensitivity (control systems) business |
| Zdroj: | Lab on a chip. 4(2) |
| ISSN: | 1473-0197 |
| Popis: | Nanotechnology promises to enhance the functionality and sensitivity of miniaturized analytical systems. For example, nanoscale transport systems, which are driven by molecular motors, permit the controlled movement of select cargo along predetermined paths. Such shuttle systems may enhance the detection efficiency of an analytical system or facilitate the controlled assembly of sophisticated nanostructures if transport can be coordinated through complex track networks. This study determines the feasibility of complex track networks using kinesin motor proteins to actively transport microtubule shuttles along micropatterned surfaces. In particular, we describe the performance of three basic structural motifs: (1) crossing junctions, (2) directional sorters, and (3) concentrators. We also designed track networks that successfully sort and collect microtubule shuttles, pointing the way towards lab-on-a-chip devices powered by active transport instead of pressure-driven or electroosmotic flow. |
| Databáze: | OpenAIRE |
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