Electrophilic cyclization of o-acetoxy and o-benzyloxy alkynylpyridines: an easy entry into 2,3-disubstituted furopyridines

Autor:	Fabio Marinelli, Giancarlo Fabrizi, Sandro Cacchi, Antonio Arcadi, Di Giuseppe S
Jazyk:	angličtina
Rok vydání:	2002
Předmět:	chemistry.chemical_compound Chemistry Cyclization Pyridines Organic Chemistry Electrophile Indicators and Reagents HIV Protease Inhibitors Physical and Theoretical Chemistry Furans Biochemistry Medicinal chemistry Carbon monoxide
Popis:	[reaction: see text] 2,3-Disubstituted furo[3,2-b]pyridines, 2,3-disubstituted furo[2,3-b]pyridines, and 2,3-disubstituted furo[2,3-c]pyridines are readily prepared under mild conditions via the palladium-catalyzed cross-coupling of 1-alkynes with o-iodoacetoxy- or o-iodobenzyloxypyridines, followed by electrophilic cyclization by I(2) or by PdCl(2) under a balloon of carbon monoxide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe7d31fbca7f4887556e2c900b3a61a http://hdl.handle.net/11697/14911 Zobrazit plný text záznamu