Engraftment with chronic granulocytic leukemia cells in acute myeloid leukemia
| Autor: | A.S.D. Spiers, N. A. Buskard, JohnM. Goldman, David A. G. Galton, Juginder Kaur |
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| Rok vydání: | 1979 |
| Předmět: |
Male
Cytotoxic drug medicine.medical_treatment Immunology Remission Spontaneous Clone (cell biology) Bone Marrow Cells hemic and lymphatic diseases medicine Chromosomes Human 21-22 and Y Immunology and Allergy Cytotoxic T cell Humans Transplantation Homologous Cells Cultured Chemotherapy business.industry Myeloid leukemia Hematology Chronic granulocytic leukemia Middle Aged In vitro Leukemia Myeloid Acute medicine.anatomical_structure Leukemia Myeloid Bone marrow business Granulocytes |
| Zdroj: | Transfusion. 19(3) |
| ISSN: | 0041-1132 |
| Popis: | A deliberate engraftment with nonirradiated chronic granulocytic leukemia (CGL) cells was performed in a patient with acute myeloid leukemia (AML) at a time when he was resistant to cytotoxic drug chemotherapy, pancytopenic and developed an infection. The CGL engraftment was confirmed by the presence of a Ph1-positive donor clone in the recipient's bone marrow and by the pattern of colony growth of the recipient's bone-marrow cells cultured in vitro. Bone marrow engraftment in the host helped in the resolution of infection and permitted the administration of further cytotoxic drugs, as a result of which a remission of AML occurred. |
| Databáze: | OpenAIRE |
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