Photobiomodulation induces murine macrophages polarization toward M2 phenotype

Autor:	Valdison Pereira dos Reis, Alex Augusto Ferreira e Ferreira, Maria Naiara Macedo Tavares, Cristina Matiele Alves Rego, Andreimar M. Soares, Charles Nunes Boeno, Juliana P. Zuliani, Stella Regina Zamuner, Jéssica Amaral Lopes, Mauro Valentino Paloschi
Rok vydání:	2021
Předmět:	biology Chemistry Macrophages Venom Inflammation Toxicology biology.organism_classification Mice Phenotype M2 phenotype Crotalid Venoms medicine Cancer research Animals Bothrops Macrophage Low-Level Light Therapy medicine.symptom ARG1 Gene Transforming growth factor
Zdroj:	Toxicon. 198:171-175
ISSN:	0041-0101
DOI:	10.1016/j.toxicon.2021.05.009
Popis:	Photobiomodulation using light-emitting diode (LED) treatment has analgesic and anti-inflammatory effects which can be an effective therapeutic associated with serum therapy for local treatment of snakebites. Here we explored the effects of LED treatment on isolated macrophage under Bothrops jararacussu venom. Results showed that LED induced IL-6 and TNF-α genes down-regulation and, TGF and ARG1 genes up-regulation which indicates a polarization of macrophages to an M2 phenotype contributing to both tissue repair and resolution of inflammation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe79643a54268adf2793491103fce05 https://doi.org/10.1016/j.toxicon.2021.05.009 Zobrazit plný text záznamu Full Text from ScienceDirect