Automation of toxicological screenings on a Hewlett Packard Chemstation GC-MS system
| Autor: | Viviane Maes, Tom Fiers, Claude Sevens |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Decision support system
Illicit Drugs business.industry Computer science Nordazepam Clinical Biochemistry General Medicine Modular design Toxicology computer.software_genre Sensitivity and Specificity Automation Gas Chromatography-Mass Spectrometry Expert system Software Humans Software design Macro Software engineering business computer Decision analysis |
| Zdroj: | Clinical Biochemistry. 29:357-361 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/0009-9120(96)00044-6 |
| Popis: | Objectives: To optimize the interpretation of GC-MS toxicological screenings (i.e., to facilitate ion specific queries, create custom reports specifically adapted to each confirmation procedure, and eliminate redundant and/or inaccurate data on library search reports). Design and Methods: The MS Chemstation software of the Hewlett Packard 5972 is constructed in a modular way. We made extensive modifications to two modules, the data analysis and the report modules, using the built-in MS Chemstation macro language. Results: Ion specific queries were automated for over 60 commonly encountered analytes. Custom reports were created for the confirmation of positive drugs-of-abuse immunoassay results. With the incorporation of decision support rules into the data processing and the reporting phases, we obtained sensitive, accurate, and concise reports. Conclusions: The MS Chemstation software can be tailored to the needs of each individual application. The incorporation of a rule-based decision support system enhances the quality of the GC-MS toxicological screenings and results in faster, easier, and more reliable processing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect