Metatheases: artificial metalloproteins for olefin metathesis
Autor: | Jun Okuda, Steve Gotzen, Daniel F. Sauer |
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Rok vydání: | 2016 |
Předmět: |
chemistry.chemical_classification
Olefin metathesis 010405 organic chemistry Ligand Organic Chemistry chemistry.chemical_element Alkenes 010402 general chemistry 01 natural sciences Biochemistry Catalysis 0104 chemical sciences Ruthenium chemistry.chemical_compound Protein structure chemistry Biomimetic Materials Metalloproteins Metalloprotein Organic chemistry Physical and Theoretical Chemistry Selectivity Carbene |
Zdroj: | Organic & Biomolecular Chemistry. 14:9174-9183 |
ISSN: | 1477-0539 1477-0520 |
DOI: | 10.1039/c6ob01475e |
Popis: | The incorporation of organometallic catalyst precursors in proteins results in so-called artificial metalloenzymes. The protein structure will control activity, selectivity and stability of the organometallic site in aqueous medium and allow non-natural reactions in biological settings. Grubbs-Hoveyda type ruthenium catalysts with an N-heterocyclic carbene (NHC) as ancillary ligand, known to be active in olefin metathesis, have recently been incorporated in various proteins. An overview of these artificial metalloproteins and their potential application in olefin metathesis is given. |
Databáze: | OpenAIRE |
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