Metatheases: artificial metalloproteins for olefin metathesis

Autor: Jun Okuda, Steve Gotzen, Daniel F. Sauer
Rok vydání: 2016
Předmět:
Zdroj: Organic & Biomolecular Chemistry. 14:9174-9183
ISSN: 1477-0539
1477-0520
DOI: 10.1039/c6ob01475e
Popis: The incorporation of organometallic catalyst precursors in proteins results in so-called artificial metalloenzymes. The protein structure will control activity, selectivity and stability of the organometallic site in aqueous medium and allow non-natural reactions in biological settings. Grubbs-Hoveyda type ruthenium catalysts with an N-heterocyclic carbene (NHC) as ancillary ligand, known to be active in olefin metathesis, have recently been incorporated in various proteins. An overview of these artificial metalloproteins and their potential application in olefin metathesis is given.
Databáze: OpenAIRE