Shaping of discrete auditory inputs to extramodular zones of the lateral cortex of the inferior colliculus
| Autor: | Mark L. Gabriele, William A. Noftz, Jeremiah P. C. Stinson, Isabel D. Lamb-Echegaray |
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| Rok vydání: | 2019 |
| Předmět: |
Inferior colliculus
Male Histology Auditory Pathways Biology Somatosensory system 050105 experimental psychology Article 03 medical and health sciences 0302 clinical medicine Cortex (anatomy) Afferent medicine Animals 0501 psychology and cognitive sciences Gene Knock-In Techniques Postnatal day Projection (set theory) Glutamate Decarboxylase General Neuroscience 05 social sciences Inferior Colliculi Mice Inbred C57BL Neuroanatomical Tract-Tracing Techniques Patch matrix medicine.anatomical_structure Female Anatomy Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain Struct Funct |
| ISSN: | 1863-2661 |
| Popis: | The multimodal lateral cortex of the inferior colliculus (LCIC) exhibits a modular-extramodular micro-organization that is evident early in development. In addition to a set of neurochemical markers that reliably highlight its modular-extramodular organization (e.g. modules: GAD67-positive, extramodular zones: calretinin-positive, CR), mature projection patterns suggest that major LCIC afferents recognize and adhere to such a framework. In adult mice, distinct afferent projections appear segregated, with somatosensory inputs targeting LCIC modules and auditory inputs surrounding extramodular fields. Currently lacking is an understanding regarding the development and shaping of multimodal LCIC afferents with respect to its emerging modular-extramodular microarchitecture. Combining living slice tract-tracing and immunocytochemical approaches in GAD67-GFP knock-in mice, the present study characterizes the critical period of projection shaping for LCIC auditory afferents arising from its neighboring central nucleus (CNIC). Both crossed and uncrossed projection patterns exhibit LCIC extramodular mapping characteristics that emerge from initially diffuse distributions. Projection mismatch with GAD-defined modules and alignment with encompassing extramodular zones becomes increasingly clear over the early postnatal period (birth to postnatal day 12). CNIC inputs terminate almost exclusively in extramodular zones that express CR. These findings suggest multimodal LCIC inputs may initially be sparse and intermingle, prior to segregation into distinct processing streams. Future experiments are needed to determine the likely complex interactions and mechanisms (e.g. activity-dependent and independent) responsible for shaping early modality-specific LCIC circuits. |
| Databáze: | OpenAIRE |
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