A collaborative study to establish the 3rd WHO International Standard for hepatitis B virus for nucleic acid amplification techniques
| Autor: | Jacqueline F. Fryer, Alan B. Heath, Dianna E. Wilkinson, Philip D. Minor |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pharmacology
Hepatitis B virus General Immunology and Microbiology International Cooperation Reproducibility of Results Bioengineering General Medicine 030204 cardiovascular system & hematology Reference Standards World Health Organization Applied Microbiology and Biotechnology 03 medical and health sciences 0302 clinical medicine Freeze Drying Immunology and Microbiology(all) DNA Viral Humans Nucleic Acid Amplification Techniques 030215 immunology Biotechnology |
| Zdroj: | Biologicals : journal of the International Association of Biological Standardization. 46 |
| ISSN: | 1095-8320 |
| Popis: | Nucleic acid amplification techniques (NAT) are routinely used for clinical diagnostics and monitoring hepatitis B virus (HBV) infections, and are implemented on a voluntary basis for blood screening. A collaborative study was performed to evaluate a replacement WHO International Standard for HBV for the standardization of NAT. Two lyophilised HBV candidates were evaluated by 16 laboratories worldwide, alongside the existing HBV International Standard. The overall mean potency estimates for the candidate samples 1 and 2, relative to sample 3 (2nd HBV International Standard), from quantitative assays, were 5.93 and 5.98 log |
| Databáze: | OpenAIRE |
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