Chronic ethanol forced administration from adolescence to adulthood reduces cell density in the rat spinal cord
| Autor: | Ana Carolina Alves Oliveira, Bruna Puty, Rafael Rodrigues Lima, Cristiane Socorro Ferraz Maia, Rafael Monteiro Fernandes, Priscila Cunha Nascimento, Leonardo Oliveira Bittencourt, Luana Ketlen Reis Leão, Luanna Melo Pereira Fernandes, Sabrina C. Cartágenes |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Cell type Programmed cell death Alcohol Drinking Central nervous system Cell Count Biology White matter 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine mental disorders Parenchyma medicine Animals Rats Wistar Motor Neurons Ethanol Neurodegeneration Water Cell Biology General Medicine medicine.disease Spinal cord White Matter 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Spinal Cord 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Tissuecell. 55 |
| ISSN: | 1532-3072 |
| Popis: | Ethanol (EtOH) consumption is a risk factor for central nervous system damage, especially during adolescence. This study aimed to investigate the possible effects of chronic EtOH forced administration on gray and white matter of the spinal cord, from adolescence to adulthood. For this, male Wistar rats were administered EtOH by gavage (6.5 g/kg/day; 22.5% w/v) from the 35th to the 90th day of life, while control animals received only distilled water. After exposure, animals were euthanized and their spinal cords processed to obtain cervical and thoracic segments for histological analyses. Quantitative analyses of total cell density and motor neurons of white and gray matter from the ventral horns were evaluated. Forced EtOH administration model showed a decrease in the motoneuron density in the spinal cord in both segments evaluated. Analyses of total cell density showed that the cervical segment was more susceptible to damages promoted by EtOH, with a significant decrease in cell density. Our results showed that chronic EtOH exposure during adolescence could promote injuries to the spinal cord, with neurodegeneration of motoneurons and other cell types present in neural parenchyma. |
| Databáze: | OpenAIRE |
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