Beneficial effects of murtilla extract and madecassic acid on insulin sensitivity and endothelial function in a model of diet-induced obesity
| Autor: | Marta Gil-Ortega, María S. Fernández-Alfonso, Miriam Martín-Ramos, Marta Viana, Silvia M. Arribas, Carla Delporte, Jorge Arancibia-Radich, Martín Alcalá, Raquel González-Blázquez, Beatriz Somoza |
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| Přispěvatelé: | USPCEU. Departamento de Química y Bioquímica, USPCEU. Grupo de Metabolismo y Función Vascular (MET-VASC) |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Antioxidant Myrtaceae medicine.medical_treatment lcsh:Medicine Pharmacology Mice chemistry.chemical_compound 0302 clinical medicine Insulin Extrac Phosphorylation Endothelial dysfunction lcsh:Science Aorta Protein Tyrosine Phosphatase Non-Receptor Type 1 Multidisciplinary myr Murtilla Insulin sensitivity Endothelial function Myricetin Nitric Oxide Synthase Type III Medicina Diet High-Fat Nitric Oxide Article Nitric oxide 03 medical and health sciences Insulin resistance medicine.artery Beneficial effect Ethyl acetate extract medicine Animals Obesity Plant Extracts lcsh:R medicine.disease Triterpenes Mice Inbred C57BL Plant Leaves Disease Models Animal 030104 developmental biology chemistry lcsh:Q Endothelium Vascular Insulin Resistance Proto-Oncogene Proteins c-akt 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) Biblos-e Archivo. Repositorio Institucional de la UAM instname |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-36555-1 |
| Popis: | Infusions of murtilla leaves exhibit antioxidant, analgesic, and anti-inflammatory properties. Several compounds that are structurally similar to madecassic acid (MA), a component of murtilla leaf extract (ethyl acetate extract, EAE), have been shown to inhibit protein tyrosine phosphatase 1B (PTP1P). The aim of this study was to evaluate if EAE and two compounds identified in EAE (MA and myricetin [MYR]) could have a beneficial effect on systemic and vascular insulin sensitivity and endothelial function in a model of diet-induced obesity. Experiments were performed in 5-week-old male C57BL6J mice fed with a standard (LF) or a very high-fat diet (HF) for 4 weeks and treated with EAE, MA, MYR, or the vehicle as control (C). EAE significantly inhibited PTP1B. EAE and MA, but not MYR, significantly improved systemic insulin sensitivity in HF mice and vascular relaxation to Ach in aorta segments, due to a significant increase of eNOS phosphorylation and enhanced nitric oxide availability. EAE, MA, and MYR also accounted for increased relaxant responses to insulin in HF mice, thus evidencing that the treatments significantly improved aortic insulin sensitivity. This study shows for the first time that EAE and MA could constitute interesting candidates for treating insulin resistance and endothelial dysfunction associated with obesity. This study was supported by BFU2011-25303, GR921645-Santander, Fundación Mutua Madrileña, Fundación Eugenio Rodríguez Pascual, SESCAMET, project FONDECYT1130155, grant CONICYT de Doctorado Nacional, grant CONICYT de Apoyo de Tesis 21130672, and grant CONICYT de Pasantía Doctoral |
| Databáze: | OpenAIRE |
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