Multiple myeloma: therapeutic delivery of antibodies and aptamers

Autor:	Paul A. Mulheran, Mohammed M. Al Qaraghuli, Karina Kubiak-Ossowska, Valerie A. Ferro, Neret Pujol-Navarro, Elpiniki Paspali, Gillian A. Horne, Mark Williams, Richard Soutar, Manal Alsaadi
Rok vydání:	2021
Předmět:	RM medicine.medical_specialty biology business.industry Aptamer Pharmaceutical Science medicine.disease Hematological malignancy Modelling methods medicine biology.protein Humans Antibody Treatment resistance Intensive care medicine Antibody therapy business Multiple Myeloma Multiple myeloma
Zdroj:	Therapeutic delivery. 12(10)
ISSN:	2041-6008 2041-5990
Popis:	Multiple myeloma is the second most common hematological malignancy in adults, accounting for 2% of all cancer-related deaths in the UK. Current chemotherapy-based regimes are insufficient, as most patients relapse and develop therapy resistance. This review focuses on current novel antibody- and aptamer-based therapies aiming to overcome current therapy limitations, as well as their respective limitations and areas of improvement. The use of computer modeling methods, as a tool to study and improve ligand-receptor alignments for the use of novel therapy development will also be discussed, as it has become a rapid, reliable and comparatively inexpensive method of investigation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdf6be9225a614462c79d65e98a9c33 https://pubmed.ncbi.nlm.nih.gov/34569269 Zobrazit plný text záznamu