Autoantibody against B lymphocytes
| Autor: | Domenico Bernoco, Min Sik Park, PaulI. Terasaki |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
B-Lymphocytes Histocompatibility Testing Autoantibody Temperature General Medicine Biology medicine.disease Cytotoxicity Tests Immunologic Kidney Transplantation Cold Temperature Incubation temperature Antibody response Isoantibodies Immunology medicine biology.protein Cytotoxic T cell Humans Female Antibody Kidney transplantation Autoantibodies |
| Zdroj: | Lancet (London, England). 2(8036) |
| ISSN: | 0140-6736 |
| Popis: | The sera of 20 out of 99 (20%) normal males and females were shown to have antibodies that kill their own B lymphocytes. The sera were specifically cytotoxic to B lymphocytes and not T lymphocytes. Allogeneic B lymphocytes were also killed by these autocytotoxins. Maximum killing of B lymphocytes occurred when the incubation temperature in serum was 5 degrees C and complement incubation temperature was 20 degrees C. Under these cold conditions, some sera reacted up to a dilution of 1/16. These results suggest that positive B-lymphocyte crossmatches found in kidney transplantation do not detect alloantibodies. Since the B-cell autoantibodies tend to appear at the time of immunisation, their role as autoregulators of the antibody response is an intriguing possibility. |
| Databáze: | OpenAIRE |
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