Nesprin isoforms: are they inside or outside the nucleus?
| Autor: | Glenn E. Morris, K. Natalie Randles |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cell Nucleus
Nesprin Nuclear Envelope Microfilament Proteins Active Transport Cell Nucleus Nuclear Proteins Nerve Tissue Proteins Biology Biochemistry Cell biology Cytoskeletal Proteins Cell nucleus medicine.anatomical_structure Cytoplasm medicine Animals Humans Protein Isoforms Nuclear lamina Inner membrane Nuclear protein Nuclear transport Lamin |
| Zdroj: | Biochemical Society Transactions. 38:278-280 |
| ISSN: | 1470-8752 0300-5127 |
| DOI: | 10.1042/bst0380278 |
| Popis: | The giant isoforms of nesprins 1 and 2 are emerging as important players in cellular organization, particularly in the positioning of nuclei, and possibly other organelles, within the cytoplasm. The experimental evidence suggests that nesprins also occur at the inner nuclear membrane, where they interact with the nuclear lamina. In this paper, we consider whether this is consistent with current ideas about nesprin anchorage and about mechanisms for nuclear import of membrane proteins. |
| Databáze: | OpenAIRE |
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