Use of cryomicrotomy to study gastric diffusion of amoxicillin in guinea pigs
| Autor: | J. Floquet, J.C. Burdin, A. Le Faou, M. C. Conroy, P. Franck, J.D. de Korwin, M Weber, Alain Lozniewski |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.drug_class Guinea Pigs Antibiotics Injections Intramuscular Gastroenterology Diffusion Guinea pig Pharmacokinetics Internal medicine Gastric mucosa medicine Animals Pharmacology (medical) Antibacterial agent Pharmacology Gastric Juice business.industry Stomach digestive oral and skin physiology Amoxicillin digestive system diseases Infectious Diseases medicine.anatomical_structure Gastric Mucosa business Cryoultramicrotomy Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 39:766-768 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.39.3.766 |
| Popis: | Cryomicrotomy has been used as a new technique for removing gastric mucosae from adult guinea pigs for the study of amoxicillin secretion across gastric mucosae. This method allowed a very regular thickness of the removed surface layer of mucosa to be obtained with good reproducibility. Gastric superficial mucosa concentrations and gastric juice concentrations of amoxicillin were determined 1, 2, and 4 h after intramuscular administration (50 mg/kg) in 21 guinea pigs by a microbiological method. No antibiotic was detected in gastric samples at 4 h, except for a low-level mucosal concentration in one animal, thus indicating the short time that amoxicillin is present in gastric samples. |
| Databáze: | OpenAIRE |
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