Au NPs decorated holey g-C3N4 as a dual-mode sensing platform of SERS and SALDI-MS for selective discrimination of L-cysteine

Autor: Jingxuan Pei, Yibo Sun, Xiang Yu, Zhenfei Tian, Shuting Zhang, Songbo Wei, Yanfang Zhao, Rabah Boukherroub
Přispěvatelé: China University of Geosciences [Beijing], Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), This work was supported by the National Natural Science Foundation of China [grant number 51571183] and the 2021 Graduate Innovation Fund Project of China University of Geosciences, Beijing [grant number ZY2021YC002].
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Colloid and Interface Science
Journal of Colloid and Interface Science, 2022, 626, pp.608-618. ⟨10.1016/j.jcis.2022.06.176⟩
ISSN: 0021-9797
1095-7103
DOI: 10.1016/j.jcis.2022.06.176⟩
Popis: International audience; Development of reliable sensing strategy combining surface-enhanced Raman scattering (SERS) and surface-assisted laser desorption/ionization-mass spectrometry (SALDI-MS) is of significant interest to distinguish cysteine enantiomers in body fluid for understanding their physiological roles and toxicity hazards. In this work, a SERS/SALDI-MS dual-mode sensing platform of gold nanoparticles (Au NPs) decorated holey carbon nitride (hg-C3N4) was fabricated for sensitive detecting cysteine. The designed Au@hg-C3N4 matrix featured a uniform distribution of Au NPs with the help of anchoring effect of hg-C3N4 holey structure, which was conducive to produce highly repeatable signals. Moreover, the combination of Au NPs and holey g-C3N4 endowed this matrix with superior enrichment capacity, enhanced charge transfer and strong UV absorption. These merits allowed the matrix to acquire high sensitivity and enhanced reproducibility for l-cysteine by means of SERS/SALDI-MS. Likewise, reliable detection of l-cysteine and efficient recognition of d-cysteine in human serum jointly revealed its prospect for detecting cysteine enantiomers in body fluids. This work offers a reliable SERS/SALDI-MS strategy for determining L/D-cysteine enantiomers, and the designed Au@hg-C3N4 matrix becomes a potential application candidate for selective detection of bio-enantiomers.
Databáze: OpenAIRE
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