RUNX1 suppresses breast cancer stemness and tumor growth
| Autor: | Kristiaan H. Finstad, Janet L. Stein, Mark Fitzgerald, Andrew J. Fritz, Jane B. Lian, Jon E. Ramsey, Viens Al, Deli Hong, Gary S. Stein |
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| Rok vydání: | 2018 |
| Předmět: |
Biology
law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Text mining law In vivo hemic and lymphatic diseases medicine skin and connective tissue diseases Transcription factor 030304 developmental biology 0303 health sciences business.industry medicine.disease Phenotype 3. Good health RUNX1 chemistry 030220 oncology & carcinogenesis embryonic structures Cancer research Suppressor Ectopic expression business |
| DOI: | 10.1101/315093 |
| Popis: | SummaryRecent studies have revealed that mutations in the transcription factor Runx1 are prevalent in breast tumors. Yet, how loss of Runx1 contributes to breast cancer (BCa) remains unresolved. We demonstrate for the first time that Runx1 represses the breast cancer stem cell (BCSC) phenotype and consequently, functions as a tumor suppressor in breast cancer. Runx1 ectopic expression in MCF10AT1 and MCF10CA1a BCa cells reduces (60%) migration, invasion and in vivo tumor growth in mouse mammary fat pad (P |
| Databáze: | OpenAIRE |
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